Abnormal Reproductive Development in Rats after Neonatally Administered Antiestrogen (Tamoxifen)
نویسندگان
چکیده
منابع مشابه
Testosterone levels and histological features of reproductive glands in adult male rats treated neonatally with tamoxifen.
OBJECTIVE In this study we examined the possibility that demasculinization produced by the neonatal administration of tamoxifen is accompanied by a decline in plasma levels of testosterone during adulthood. METHODS Wistar male rats received either a treatment with 12.5 microg/kg of tamoxifen during the first eight days of age or a treatment with 100 microg/kg of tamoxifen for five days. Each ...
متن کاملNeonatally induced mild diabetes: influence on development, behavior and reproductive function of female Wistar rats
BACKGROUND Neonatal STZ treatment induces a state of mild hyperglycemia in adult rats that disrupts metabolism and maternal/fetal interactions. The aim of this study was investigate the effect of neonatal STZ treatment on the physical development, behavior, and reproductive function of female Wistar rats from infancy to adulthood. METHODS At birth, litters were assigned either to a Control (s...
متن کاملEffects of neonatally administered sex steroids on 7,12-dimethylbenz(a)anthracene-induced mammary neoplasia in rats.
Female Sprague-Dawley 5-day-old rats were given s.c. either 0.05 ml sesame oil, 1.25 mg progesterone, 0.1 mg estradici benzoate, or 1.25 mg testosterone propionate. At 55 days of age all rats were given 20 mg of 7,12-dimethylbenz(a)anthracene (DMBA) by stomach tube. All rats were killed at 190 days of age. Both the estradiol and the testosterone propionate treatments decreased the mammary adeno...
متن کاملDevelopment of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration.
Long-term tamoxifen (TAM) therapy was examined in athymic mice bearing MCF-7 tumors of different sizes. Six months of TAM treatment caused no increase in tumor size (compared to placebo treatment) for animals treated initially following implantation of tumor pieces (approximately 1 mm3) or for animals with 0.2-cm2 tumors (grown with 1 month of estrogen treatment). Tumors could be regrown with e...
متن کاملDevelopment of Tamoxifen-stimulated Growth of MCF-7 Tumors in Athymic Mice after Long-Term Antiestrogen Administration1
Long-term tamoxifen (TAM) therapy was examined in athymic mice bearing MCF-7 tumors of different sizes. Six months of TAM treatment caused no increase in tumor size (compared to placebo treatment) for animals treated initially following implantation of tumor pieces (approx imately 1 mm3) or for animals with 0.2-cm2 tumors (grown with 1 month of estrogen treatment). Tumors could be regrown with ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1979
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod21.5.1087